|
KMID : 1140120050100020073
|
|
Cancer Prevention Research
2005 Volume.10 No. 2 p.73 ~ p.80
|
|
|
Induction of Cell Cycle Arrest and Apoptotic Cell Death by Resveratrol, a Polyphenolic Phytoalexin, in Human Cancer Cells
|
|
Choi Yung-Hyun
|
|
|
Abstract
|
|
|
|
Chemoprevention is a promising approach to control human cancer. The polyphenolic compound resveratrol is a naturally occurring phytochemical and present in a variety of plant species, including food products like grapes and peanuts, and it is also present in red wine and various herbs. Resveratrol has been examined in several model systems for its potential effect against cancer. Its anti-cancer effects include its role as a chemopreventive agent, its ability to inhibit cell proliferation, its direct effect in cytotoxicity by induction of apoptosis and its potential therapeutic effect in pre-clinical studies. However, the precise mechanism explaining its anti-carcinogenic effect is not clear. This review summarizes recent studies on the mechanisms of cell cycle arrest and apoptotis induction by resveratrol in human cancer cells.
|
|
|
KEYWORD
|
|
|
Resveratrol, Cancer cells, Cell cycle, Apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|